You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. Applies only to oral form of both agents. https://www.uptodate.com/ (Requires subscription). Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Equations : Total body iron deficit (mg) = body weight (kg) x (target Hb - actual Hb in g/dL) x 2.4 + iron depot (mg)** [1, 2] Iron depot: 15 mg/kg for body weight less than 35 kg 500 mg for those with a body weight greater than or equal to 35 kg Ideal Body Weight (kg) =45.5 +2.3 * (height inches - 60 inches) [3] Applies only to oral form of both agents. Mean Corpuscular Hemoglobin Concentration (MCHC) Calculator, Red Blood Cell (RBC) Indices Calculator, Iron Deficiency In Pregnancy Calculator. DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. Administer ciprofloxacin at least 2 hours before or 6 hours after using these products. Use Caution/Monitor. A maximum dose of 1000 mg iron can be delivered intravenously over 15 minutes, which may make it a suitable treatment for iron-deficiency anaemia outside of the hospital setting. Iron Deficiency Anemia: Periodic hematologic determination (hemoglobin and hematocrit) is a simple and accurate technique for monitoring hematological response, and should be used as a guide in therapy. Applies only to oral form of both agents. Diluted with 0.9% Sodium Chloride Injection at concentrations of 1 to 2 mg/mL, 2 doses of 300 mg/250 mL over 1.5 hrsplus1 dose of 400 mg/250 mL over 2.5 hrs. Applies only to oral form of both agents. Brand name: Venofer Drug class: Iron Preparations Chemical name: iron saccharate CAS number: 8047-67-4 Medically reviewed by Drugs.com on Oct 25, 2022. Then enter the value of the Dosage and choose the unit of measurement from the drop-down menu. Copyright 2014 - 2023 The Calculator .CO |All Rights Reserved|Terms and Conditions of Use, Parenteral Iron Replacement For Iron Deficiency Anemia Calculator, Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations, Clinical use of the total dose intravenous infusion of iron dextran, When is high-dose intravenous iron repletion needed? deferasirox decreases levels of iron sucrose by inhibition of GI absorption. If you log out, you will be required to enter your username and password the next time you visit. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Burns DL, Mascioli EA, Bistrian BR. In post-marketing safety studies of Venofer in 1,051 patients with HDD-CKD, adverse reactions reported by >1% were cardiac failure congestive, sepsis and dysgeusia. Give each dose as 750mg for a total cumulative dose not to exceed1500mg of ironper course. Medically reviewed by Drugs.com. however iron sucrose requires multiple small intermittent doses over days to weeks. 3. Intravenous therapy is preferred for urgent intervention and when oral iron cannot be absorbed or the patient suffers from chronic renal impairment. The dosing for iron replacement treatment in pediatric patients with hemodialysis-dependent chronic kidney disease (HDD-CKD), non-dialysis-dependent chronic kidney disease (NDD-CKD) or peritoneal-dialysis-dependent chronic kidney disease (PDD-CKD) has not been established. Avoid or Use Alternate Drug. The recommended Feraheme dose may be readministered to patients with persistent or recurrent iron deficiency anemia. 20 mg/mL for Iron sucrose; 5 mg/mL for Ferric gluconate. iron sucrose decreases levels of manganese by inhibition of GI absorption. Interaction only with oral iron administration. Injection site discoloration has been reported following extravasation. Generic name: IRON SUCROSE 20mg in 1mL Minor/Significance Unknown. Modify Therapy/Monitor Closely. Creating an account is free and takes less than 1 minute. Corrected Calcium. For repletion treatment most patients may require a cumulative dose of 1000 mg of elemental iron administered over 8 dialysis sessions. Modify Therapy/Monitor Closely. Serious - Use Alternative (1)iron sucrose decreases levels of ofloxacin by inhibition of GI absorption. Use Caution/Monitor. Minor (2)calcium citrate decreases levels of iron sucrose by inhibition of GI absorption. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. May increase risk of hypotension. Applies only to oral form of both agents. Do not mix iron sucrose with other medications or TPN solution. Applies only to oral form of both agents. Avoid or Use Alternate Drug. Read our. Max Dose. iron sucrose increases levels of calcium acetate by enhancing GI absorption. This drug is available at the lowest co-pay. Administer iron products at least 2 hr before and no less than 6 hr after each dose to avoid chelation with magnesium. This health tool computes the iron deficit based on patient parameters and the Ganzoni formula. Next Steps Evidence Creator Insights Dr. Andreas M. Ganzoni About the Creator . Injectafer treatment may be repeated if iron deficiency anemia reoccurs. Separate by at least 4 hours. The factor 2.4 comes about from the calculation that the total iron content of hemoglobin is 0.34%, the blood volume accounts for 7% . Hemoglobin can be input in g/dL, g/L or mmol/L and refers to the amount of hemoglobin in the red blood cells. David McAuley, Pharm.D. Assessing new treatment options, Intravenous iron-dextran: therapeutic and experimental possibilities. . This parenteral iron replacement for iron deficiency anemia calculator determines the parenteral dose of iron supplement needed to replenish iron stores and hemoglobin levels. Ferritin and transferrin are also recommended monitoring . For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every four weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes. Dosing Administration & Considerations . (3) Known hypersensitivity to Venofer. Steps on how to print your input & results: 1. USES: This medicine is used to treat "iron-poor" blood (anemia) in people with long-term kidney disease. This site complies with the HONcode standard for trust- worthy health information: verify here. HOW TO USE: This medication is given by injection into a vein as directed by your doctor. Philadelphia, PA: Lippincott Williams & Wilkins;2013;303-307. Use Caution/Monitor. Minor/Significance Unknown. Use Caution/Monitor. Use Caution/Monitor. Indications: Feraheme is indicated for the treatment of iron deficiency anemia (IDA) in adult patients: who have intolerance to oral iron or have had unsatisfactory response to oral iron or who have chronic kidney disease (CKD). Use Caution/Monitor. Untreated IDA in pregnancy is associated with adverse maternal outcomes such as post-partum anemia. It is usually given slowly over 2 to 5 minutes or as directed by your doctor. Minor/Significance Unknown.iron sucrose increases levels of calcium chloride by enhancing GI absorption. ibuprofen/famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. Each mL contains 20 mg of elemental iron. Parenteral iron dextran therapy. Baloxavir may bind to polyvalent cations resulting in decreased absorption. Either decreases levels of the other by inhibition of GI absorption. 1970;100(7):301303. Avoid or Use Alternate Drug. Applies only to oral form of both agents. Both the 200- and 300-mg doses of IV iron sucrose administered over 2 hours appear to be safe. Manufacturer advises for slow intravenous injection ( Venofer ), give undiluted at a rate of 1 mL/minute; do not exceed 10 mL (200 mg iron) per injection. Applies only to oral form of both agents. Avoid or Use Alternate Drug. Venofer and the Venofer logo are registered trademarks of Vifor (International) Inc., Switzerland. Use Caution/Monitor. We first individually analyzed 5 clinical studies, averaging the total iron deficit across all patients utilizing a . Assessing new treatment options. 1) Ganzoni AM. elemental iron (mg/ml) in the product being used: Where C= If you miss a dose, ask your doctor or pharmacist right away for a new dosing schedule. Excessive therapy with parenteral iron can lead to excess storage of iron with the possibility of iatrogenic hemosiderosis. Applies only to oral form of both agents. Iron sucrose: 20 mg/mL. didanosine will decrease the level or effect of iron sucrose by increasing gastric pH. Objective. Sodium ferric gluconate (Ferrlecit) 62.5 mg . The therapeutic management of IDA focuses on the replenishment of the iron stores through methods that have been mentioned above. Total dose iron infusion: safety and efficacy in predialysis patients. Where C is the concentration of the iron product: Please note that the calculations above are for information purposes only and the individual dose needs to be established by taking into account the current package insert for the elemental iron product used. Applies only to oral form of both agents. Kumpf VJ. This calculator will help pinpoint potential causes of anemia based on Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when Venofer is injected. Human studies not conducted. Monitor Closely (1)deferasirox decreases levels of iron sucrose by inhibition of GI absorption. Normal haemoglobin values are gender specific: for males from 13.8 to 18.0 g/dL (138 to 180 g/L, or 8.56 to 11.17mmol/L) and females from 12.1 to 15.1 g/dL (121 to 151 g/L, or 7.51 to 9.37mmol/L). Applies only to oral form of both agents. Administer iron products at least 2 hr before and no less than 6 hr after each dose to avoid chelation with magnesium. 2. Minor/Significance Unknown. Adding plans allows you to compare formulary status to other drugs in the same class. Minor/Significance Unknown. Use Caution/Monitor. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every two weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes. Separate dosing of tetracyclines from these products. This website is intended for use by US healthcare professionals only. You can further save the PDF or print it. Talk to your pharmacist for more details.During pregnancy, this medication should be used only when clearly needed. Either increases effects of the other by pharmacodynamic synergism. These are real scientific discoveries about the nature of the human body, which can be invaluable to physicians taking care of patients. Use Caution/Monitor. 1 Dosing for patients who weigh less than 50 kg There are physiological variation in iron reserves such as the decrease during menstruation period. Use Caution/Monitor. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. After total replacement dose completed, need for ongoing IV doses should be re-assessed monthly. Please note that once you have closed the PDF you need to click on the Calculate button before you try opening it again, otherwise the input and/or results may not appear in the pdf. Do Not Copy, Distribute or otherwise Disseminate without express permission. Applies only to oral form of both agents. Either increases effects of the other by pharmacodynamic synergism. The elemental iron product used is Iron sucrose 20 mg/mL. Use INFeD only in patients in whom clinical and laboratory investigations have established an iron deficient state not amenable to oral iron therapy. Volume of iron sucrose needed = 60 x (14 - 8) x (2.145) 20 = 38.6 mL . Sodium ferric gluconate complex injection [ Ferrlecit ] [package insert] - Elemental iron: 12.5 mg/mL (5 mL). It varies from increases in dietary intake of iron (usually for prophylaxis purposes) to oral, intramuscular or intravenous therapy. You will have to pay for your IV iron. Monitor Closely (1)esomeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. The factor 2.4 is derived from the following assumptions: a) Blood volume 70 ml/kg of body weight ~7% of body weight b) Iron content of hemoglobin 0.34% Factor 2.4 = 0.0034 x 0.07 x 10000 (conversion for g/dL) Ganzoni AM. Share cases and questions with Physicians on Medscape consult. In most cases, adult patients require a cumulative dose of elemental iron of at least 1 g. Most commonly, iron replenishment therapy is done intravenously: As total dose (iron-dextran or iron carboxymaltose); Iron deficiency is common during childhood growth, prolonged periods of sickness, in convalescence or during pregnancy. Applies only to oral form of both agents. Serious - Use Alternative (1)iron sucrose decreases levels of tetracycline by inhibition of GI absorption. Reference www.medicines.org.uk Background IDA symptoms are often nonspecific and include tiredness, weakness, shortness of breath. Separate by 2 hr. Serious - Use Alternative (1)iron sucrose decreases levels of gemifloxacin by inhibition of GI absorption. iron sucrose decreases levels of ciprofloxacin by inhibition of GI absorption. Applies only to oral form of both agents. Administer Venofer in 3 divided doses, given by slow intravenous infusion, within a 28 day period: 2 infusions each of 300 mg over 1.5 hours 14 days apart followed by one 400 mg infusion over 2.5 hours 14 days later. Minor (2)calcium acetate decreases levels of iron sucrose by inhibition of GI absorption. Applies only to oral form of both agents. During all INFeD administrations, observe for signs or symptoms of anaphylactic-type reactions. Applies only to oral form of both agents. Most Otherwise, call a poison control center right away. Iron deficiency can occur at any stage of life, due to physiological demands, for example, during pregnancy, childhood growth or prolonged periods of sickness. All Rights Reserved. Use Caution/Monitor. 2010;18(3). For all products, slow initial infusion is prudent; the patient is observed closely for infusion reactions. Applies only to oral form of both agents. This drug is available at a higher level co-pay. Modify Therapy/Monitor Closely. The usual adult total treatment course of Venofer is 1000 mg. Venofer treatment may be repeated if iron deficiency reoccurs. Written by ASHP. Although anaphylactic reactions known to occur following INFeD administration are usually evident within a few minutes, or sooner, it is recommended that a period of an hour or longer elapse before the remainder of the initial therapeutic dose is given. Parenteral iron dextran therapy: a review. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Minor (2)calcium chloride decreases levels of iron sucrose by inhibition of GI absorption. Option 2: 200 mg in NS 100 mL administered over 20-30 minutes; may repeat every other day to Pediatric Patients (2 Years of Age and Older). Applies only to oral form of both agents. IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. 2000 Jan;22(1):39-43. By clicking send, you acknowledge that you have permission to email the recipient with this information. In less advanced cases of iron deficiency, increases in dietary intake of iron may be sufficient. Applies only to oral form of both agents. Use Caution/Monitor. Nutrition. Medicinal forms There are three fields in the parenteral iron replacement for iron deficiency anemia calculator: Weight can be input in either lbs or kilograms and the required transformations are performed by the calculator. Diagnosis and management of iron deficiency anaemia: a clinical update. Minor (2)calcium gluconate decreases levels of iron sucrose by inhibition of GI absorption. Use Caution/Monitor.Minor (2)calcium carbonate decreases levels of iron sucrose by inhibition of GI absorption. The following table present normal hemoglobin ranges: There is another equation for iron deficit that can be used to calculate replenishment needs, that of Ganzoni, which takes into account iron stores as well and that can be found in the iron deficit calculator. 3) Bayraktar UD, Bayraktar S. (2010) Treatment of iron deficiency anemia associated with gastrointestinal tract diseases. Iron Sucrose [ Venofer ] Elemental iron: 20 mg/mL (2.5 mL, 5 mL, 10 mL) Solution, Intravenous [preservative free]: [package insert] INDICATIONS: Venofer is an iron replacement product indicated for the treatment of iron deficiency anemia in patients with chronic kidney disease (CKD). Adult Dosage and Administration: The recommended dosage of Ferrlecit for the repletion treatment of iron deficiency in hemodialysis patients is 10 mL of Ferrlecit (125 mg of elemental iron). There is no resource limitation, as if the tool was hosted on your site, so all your users can make use of it 24/7; The necessary tool updates will take place in real time with no effort on your end; A single click install to embed it into your pages, whenever you need to use it. This cost includes the fee charged by the pharmacy. Minor/Significance Unknown. Ferumoxytol [ Feraheme ] Elemental iron: 510 mg/17 mL (17 mL) 30 mg/mL [package insert] - Boxed warning REVIEW INSERT. Minor/Significance Unknown. No additional iron to replenish stores. 0.5 mg/kg (not to exceed 100 mg/dose) diluted to a concentration of 1 to 2 mg/mL in 0.9% sodium chloride IV over 5 to 60 minutes Administer every 4 weeks for 12 weeks Do not dilute to concentrations below 1 mg/mL Comments: Treatment may be repeated if necessary. Use Caution/Monitor. Minor/Significance Unknown.iron sucrose increases levels of calcium citrate by enhancing GI absorption. Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. Administer a test INFeD dose prior to the first therapeutic dose. 1000 mg. 20 MINUTES. Use Caution/Monitor. iron sucrose, captopril. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. iron sucrose will decrease the level or effect of baloxavir marboxil by cation binding in GI tract. Applies only to oral form of both agents. (1970) Intravenous iron-dextran: therapeutic and experimental possibilities. The dosage of Venofer is expressed in mg of elemental iron. Minor/Significance Unknown. Privacy Policy, Use 500 mg for adults and children 35 kg; use 15 mg/kg if <35 kg. Applies only to oral form of both agents. Fatal reactions have followed the test dose of iron dextran injection. Consult your doctor for more details.Remember that it is best to get your vitamins and minerals from food whenever possible. The dosage of Venofer is expressed in mg of elemental iron. To provide clinicians with evidence-based guidance for iron therapy dosing in patients with iron deficiency anemia (IDA), we conducted a study examining the benefits of a higher cumulative dose of intravenous (IV) iron than what is typically administered. iron sucrose increases levels of calcium chloride by enhancing GI absorption. Administer Venofer 100 mg undiluted as a slow intravenous injection over 2 to 5 minutes, or as an infusion of 100 mg diluted in a maximum of 100 mL of 0.9% NaCl over a period of at least 15 minutes, per consecutive hemodialysis session. Serious - Use Alternative (1)iron sucrose decreases levels of fleroxacin by inhibition of GI absorption. Pain, swelling, or redness at the injection site may occur. In key trials, ferric carboxymaltose increased Hb levels and replenished iron stores as effectively as IV iron sucrose . Human studies not conducted. All Rights Reserved. Challenges in the treatment of iron deficiency include finding and addressing the underlying cause and the selection of an iron replacement product that meets the needs of the patient. Med J Aust. sodium citrate/citric acid will decrease the level or effect of iron sucrose by increasing gastric pH. Am J HealthSyst Pharm 2006;63:731735. restrictions. INDICATIONS AND USAGE: Intravenous or intramuscular injections of INFeD are indicated for treatment of patients with documented iron deficiency in whom oral administration is unsatisfactory or impossible. ------------------------------------------------------------------------- Iron Dextran Complex [ Infed ] Elemental iron: 50 mg of elemental iron per mL [2 mL] [package insert] BOXED WARNING: WARNING: RISK FOR ANAPHYLACTIC-TYPE REACTIONS Anaphylactic-type reactions, including fatalities, have followed the parenteral administration of iron dextran injection. Give each dose as 750 mg for a total cumulative dose of 1500 mg of iron per course. Medscape Education, Improving Quality of Care in Patients With Iron Deficiency Anemia and Inflammatory Bowel Disease, 2010feosol-carbonyl-fe-icar-c-carbonyl-iron-342171Drugs, encoded search term (iron sucrose (Venofer)) and iron sucrose (Venofer), Use of High-Dose Iron in Dialysis in US Tracks PIVOTAL Trial, FDA Watch List Adds Drugs With Anaphylaxis, Herpes, Fetal Death Risk, Dialysis Industry Mergers: Profits Rise as Patient Outcomes Worsen, Hematology-Oncology Guidelines: 2017 Midyear Review. *Administer early during the dialysis session. Last updated on Jun 1, 2022. iron sucrose decreases levels of deferiprone by enhancing GI absorption. Applies only to oral form of both agents. It is unlikely . Contact the applicable plan Applies only to oral form of both agents. Your list will be saved and can be edited at any time. In this study and another study evaluating a single intravenous dose of iron sucrose containing 500-700 mg of iron in 26 anemic patients on erythropoietin therapy (23 female, 3 male; age range 16-60), approximately 5% of the iron was . Anemia. Interaction only with oral iron administration. Hemoglobin there are two fields for hemoglobin input, one for the target and another for actual value. Most adults require a cumulative dose of elemental iron of at least 1 g. Iron replenishment is usually doneintravenously, via iron-dextran, iron sucrose or iron carboxymaltose. 2010niferex-hytinic-polysaccharide-iron-342160Drugs, You are being redirected to Oral and parenteral products - see background option for oral products. Dose. Avoid or Use Alternate Drug. calcium gluconate decreases levels of iron sucrose by inhibition of GI absorption. VENOFER at IV doses up to 15 mg iron/kg/dose [about 10 times the maximum recommended human dose for a 70 kg person] given three times a week was found to have no effect on fertility . lansoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Assure stable intravenous access to avoid extravasation. Slow or stop the infusion if adverse reactions occur. The recommended dosage of iron sucrose for repletion of iron deficiency in patients undergoing hemodialysis is 5ml of iron sucrose (100mg of elemental iron) delivered intravenously during the dialysis session. After administration of iron dextran complex, evidence of a therapeutic response can be seen in a few days as an increase in the reticulocyte count.

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